Section: New Results

Identification and state estimation

We identify some unknown parameters using the framework of observers.

We have used numerical observers to identify the transmission parameters of bilharzia.

We also have used observers for models with unknown inputs to identify the transmission parameters for intra-host models of malaria. We have developed a method for estimating total parasite load in falciparum malaria patients using the clinical observations of peripheral parasitaemia. We have applied this method using the data from malariatherapy. The results are illustrated in Figure 4 .

Figure 4. Estimated total parasite load (red) and parasitaemia measures (blue)